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    Science. 1988 Nov 18;242(4881):1042-5.

    Cloning of a membrane protein that induces a slow voltage-gated potassium current.

    Takumi T, Ohkubo H, Nakanishi S.

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    Institute for Immunology, Kyoto University Faculty of Medicine, Japan.

    Abstract

    A rat kidney messenger RNA that induces a slowly activating, voltage-dependent potassium current on its expression in Xenopus oocytes was identified by combining molecular cloning with an electrophysiological assay. The cloned complementary DNA encodes a novel membrane protein that consists of 130 amino acids with a single putative transmembrane domain. This protein differs from the known ion channel proteins but is involved in the induction of selective permeation of potassium ions by membrane depolarization.

    PMID:
    3194754
    [PubMed - indexed for MEDLINE]

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