Cancer Res. 1977 Jan;37(1):253-7.

Induction of gene mutations and gene conversions by vinyl chloride metabolites in yeast.

Loprieno N, Barale R, Baroncelli S, Bartsch H, Bronzetti G, Cammelini A, Corsi C, Frezza D, Nieri R, Leporini C, Rosellini D, Rossi AM.

Abstract

Chloroethylene oxide and 2-chloroacetaldehyde, two metabolites of vinyl chloride, and 2-chloroethanol, a putative metabolic intermediate, were assayed for their genetic activity in the yeasts Schizosaccharomyces pombe and Saccharomyces cerevisiae. Chloroethylene oxide was found to be the most effective in inducing forward mutations in Sch. pombe and gene conversions in S. cerevisiae, increasing the mutation and conversion frequencies 340 and 50 times, respectively, over those of the controls. In either the presence or the absence of mouse liver microsomes, 2-chloroacetaldehyde showed only feeble genetic activity, and 2-chloroethanol was completely inactive in both yeast strains. In contrast to vinyl chloride, 2-chloroacetaldehyde did not induce forward mutations in Sch. pombe inthe host-mediated assay in mice. The results strongly support the hypothesis that chloroethylene oxide is one of the principal mutagenic agents formed from vinyl chloride in the presence of mouse liver enzymes.

PMID:: 318606; [PubMed - indexed for MEDLINE]

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The mutagenicity of chloroethylene oxide, chloroacetaldehyde, 2-chloroethanol and chloroacetic acid, conceivable metabolites of vinyl chloride. [Chem Biol Interact. 1976]
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Cited by 2 PubMed Central articles

Development and application of an LC-MS/MS method for the detection of the vinyl chloride-induced DNA adduct N(2),3-ethenoguanine in tissues of adult and weanling rats following exposure to [(13)C(2)]-VC. [Chem Res Toxicol. 2010]
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Mutlu E, Collins LB, Stout MD, Upton PB, Daye LR, Winsett D, Hatch G, Evansky P, Swenberg JA. Chem Res Toxicol. 2010 Sep 20; 23(9):1485-91.
Studies on the miscoding properties of 1,N6-ethenoadenine and 3,N4-ethenocytosine, DNA reaction products of vinyl chloride metabolites, during in vitro DNA synthesis. [Nucleic Acids Res. 1981]
Studies on the miscoding properties of 1,N6-ethenoadenine and 3,N4-ethenocytosine, DNA reaction products of vinyl chloride metabolites, during in vitro DNA synthesis.
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Induction of gene mutations and gene conversions by vinyl chloride metabolites in yeast.

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