Abstract
Produced by a newly isolated Streptomycetes strain, meijiemycin is a gigantic linear polyene-polyol that exhibits structural features not seen in other members of the polyene-polyol family. We propose a biosynthetic mechanism and demonstrate that meijiemycin inhibits hyphal growth by inducing the aggregation of ergosterol and restructuring of the fungal plasma membrane.
MeSH terms
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Antifungal Agents / isolation & purification
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Antifungal Agents / metabolism
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Antifungal Agents / pharmacology*
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Candida albicans / drug effects
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Drug Discovery
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Fatty Alcohols / isolation & purification
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Fatty Alcohols / metabolism
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Fatty Alcohols / pharmacology*
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Genes, Bacterial
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Genomics
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Microbial Sensitivity Tests
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Multigene Family
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Polyenes / isolation & purification
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Polyenes / metabolism
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Polyenes / pharmacology*
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Polyketide Synthases / genetics
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Streptomyces / chemistry
Substances
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Antifungal Agents
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Fatty Alcohols
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Polyenes
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Polyketide Synthases