FEBS Lett. 1988 Nov 7;239(2):227-32.

Islet amyloid polypeptide: identification and chromosomal localization of the human gene.

Mosselman S, Höppener JW, Zandberg J, van Mansfeld AD, Geurts van Kessel AH, Lips CJ, Jansz HS.

Source

Institute of Molecular Biology, University of Utrecht, The Netherlands.

Abstract

Islet or insulinoma amyloid polypeptide (IAPP) is a 37 amino acid polypeptide isolated from pancreatic amyloid. Here, we describe the isolation and partial characterization of the human gene encoding IAPP. The DNA sequence predicts that IAPP is excised from a larger precursor protein and that its carboxy-terminus is probably amidated. The predicted normally occurring IAPP is identical to the reported polypeptides isolated from pancreatic amyloid, except for the amidated carboxy-terminus. IAPP specific polyadenylated RNAs of 1.6 kb and 2.1 kb are present in human insulinoma RNA. The human IAPP gene is located on chromosome 12.

PMID:: 3181427; [PubMed - indexed for MEDLINE]

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Research Support, Non-U.S. Gov't

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Genes and Gene Therapy - MedlinePlus Health Information

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Mouse Genome Informatics (MGI)

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Related citations in PubMed

The human islet amyloid polypeptide (IAPP) gene. Organization, chromosomal localization and functional identification of a promoter region. [FEBS Lett. 1990]
The human islet amyloid polypeptide (IAPP) gene. Organization, chromosomal localization and functional identification of a promoter region.
Christmanson L, Rorsman F, Stenman G, Westermark P, Betsholtz C. FEBS Lett. 1990 Jul 2; 267(1):160-6.
The complete islet amyloid polypeptide precursor is encoded by two exons. [FEBS Lett. 1989]
The complete islet amyloid polypeptide precursor is encoded by two exons.
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Conservation of the sequence of islet amyloid polypeptide in five mammals is consistent with its putative role as an islet hormone. [Proc Natl Acad Sci U S A. 1989]
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Review Molecular physiology of the islet amyloid polypeptide (IAPP)/amylin gene in man, rat, and transgenic mice. [J Cell Biochem. 1994]
Review Molecular physiology of the islet amyloid polypeptide (IAPP)/amylin gene in man, rat, and transgenic mice.
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Review Islet amyloid polypeptide: a review of its biology and potential roles in the pathogenesis of diabetes mellitus. [Vet Pathol. 1993]
Review Islet amyloid polypeptide: a review of its biology and potential roles in the pathogenesis of diabetes mellitus.
O'Brien TD, Butler PC, Westermark P, Johnson KH. Vet Pathol. 1993 Jul; 30(4):317-32.

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Cited by 7 PubMed Central articles

Immunoreactivity and expression of amylin in gastroenteropancreatic endocrine tumors. [Am J Pathol. 1993]
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Eissele R, Neuhaus C, Trautmann ME, Funk A, Arnold R, Höfler H. Am J Pathol. 1993 Jul; 143(1):283-91.
Increased levels of circulating islet amyloid polypeptide in patients with chronic renal failure have no effect on insulin secretion. [J Clin Invest. 1994]
Increased levels of circulating islet amyloid polypeptide in patients with chronic renal failure have no effect on insulin secretion.
Ludvik B, Clodi M, Kautzky-Willer A, Schuller M, Graf H, Hartter E, Pacini G, Prager R. J Clin Invest. 1994 Nov; 94(5):2045-50.
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Molecular and functional characterization of amylin, a peptide associated with type 2 diabetes mellitus.
Roberts AN, Leighton B, Todd JA, Cockburn D, Schofield PN, Sutton R, Holt S, Boyd Y, Day AJ, Foot EA. Proc Natl Acad Sci U S A. 1989 Dec; 86(24):9662-6.

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