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Islet amyloid polypeptide: identification and chromosomal localization of the human gene.
Institute of Molecular Biology, University of Utrecht, The Netherlands.
Islet or insulinoma amyloid polypeptide (IAPP) is a 37 amino acid polypeptide isolated from pancreatic amyloid. Here, we describe the isolation and partial characterization of the human gene encoding IAPP. The DNA sequence predicts that IAPP is excised from a larger precursor protein and that its carboxy-terminus is probably amidated. The predicted normally occurring IAPP is identical to the reported polypeptides isolated from pancreatic amyloid, except for the amidated carboxy-terminus. IAPP specific polyadenylated RNAs of 1.6 kb and 2.1 kb are present in human insulinoma RNA. The human IAPP gene is located on chromosome 12.
PMID: 3181427 [PubMed - indexed for MEDLINE]
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Cited by 7 PubMed Central articles
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Immunoreactivity and expression of amylin in gastroenteropancreatic endocrine tumors.
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[Am J Pathol. 1993]
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Increased levels of circulating islet amyloid polypeptide in patients with chronic renal failure have no effect on insulin secretion.
Ludvik B, Clodi M, Kautzky-Willer A, Schuller M, Graf H, Hartter E, Pacini G, Prager R.
J Clin Invest. 1994 Nov; 94(5):2045-50.
[J Clin Invest. 1994]
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Molecular and functional characterization of amylin, a peptide associated with type 2 diabetes mellitus.
Roberts AN, Leighton B, Todd JA, Cockburn D, Schofield PN, Sutton R, Holt S, Boyd Y, Day AJ, Foot EA.
Proc Natl Acad Sci U S A. 1989 Dec; 86(24):9662-6.
[Proc Natl Acad Sci U S A. 1989]
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