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EMBO J. 1988 Sep;7(9):2681-6.

Isolation and structural analysis of a peptide containing the novel tyrosyl-glucose linkage in glycogenin.

Author information

  • 1Department of Biochemistry, University of Dundee, UK.

Abstract

The glucosylation site on glycogenin, the protein primer required for de novo glycogen synthesis, has been identified. The glucose is attached at position C1 in a glycosidic linkage with a unique tyrosine, and the sequence surrounding this residue was found to be: His-Leu-Pro-Phe-Ile-Tyr-Asn-Leu-Ser-Ser-Ile-Ser-Ile-Tyr(Glc)-Ser-Tyr-Leu -Pro- Ala-Phe-Lys. The same tyrosine residue is glycosylated whether glycogenin is isolated as a complex with the catalytic subunit of glycogen synthase, or covalently attached to glycogen. The possibility that insulin and growth factors may enhance glycogen synthesis via stimulation of the priming reaction is discussed.

PMID:
3181138
[PubMed - indexed for MEDLINE]
PMCID:
PMC457056
Free PMC Article
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