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Cancer Genet Cytogenet. 1988 Oct 15;35(2):237-42.

Translocation (X;19) with involvement of the inactive X chromosome in oligoblastic granulocytic leukemia.

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  • 1Department of Pathology, Medical College of Pennsylvania, Philadelphia.


A 72-year-old female with metastatic breast cancer developed oligoblastic granulocytic leukemia 6 months after initiation of chemotherapy. Cytogenetic examination of the bone marrow cells revealed a balanced t(X;19)(q12;q13.3) as the sole abnormality in 50% of the metaphases. The remaining cells showed a normal female karyotype. The der(19) chromosome displayed consistent folding in the Xq13-q23 region in all metaphases, indicating involvement of the inactive X chromosome in translocation.

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