Engineering immunity for next generation HIV vaccines: The intersection of bioengineering and immunology

M Patricia D'Souza; Shyam Rele; Barton F Haynes; Dale J Hu; David L Kaplan; Shadi Mamaghani; David Rampulla

doi:10.1016/j.vaccine.2019.10.036

Engineering immunity for next generation HIV vaccines: The intersection of bioengineering and immunology

Vaccine. 2020 Jan 10;38(2):187-193. doi: 10.1016/j.vaccine.2019.10.036. Epub 2019 Nov 20.

Authors

M Patricia D'Souza¹, Shyam Rele², Barton F Haynes³, Dale J Hu¹, David L Kaplan⁴, Shadi Mamaghani⁵, David Rampulla⁶

Affiliations

¹ Division of AIDS, NIAID, Bethesda, MD, USA.
² Division of AIDS (Contractor), NIAID, Bethesda, MD, USA.
³ Duke Human Vaccine Institute, Duke University, Durham, NC, USA.
⁴ Department of Biomedical Engineering, Tufts University, Medford, MA, USA.
⁵ Division of Discovery Science and Technology (Contractor), NIBIB, Bethesda, MD, USA.
⁶ Division of Discovery Science and Technology, NIBIB, Bethesda, MD, USA.

PMID: 31759734
DOI: 10.1016/j.vaccine.2019.10.036

Abstract

Bioengineering approaches grounded in immunology have the potential for the discovery and development of a successful HIV vaccine. The overarching goal is to engineer immunity through a fusion of immunology with bioengineering to create novel strategies for the design, development and delivery of vaccines based on the controlled modulation of the immune system. To foster these collaborations, the National Institute of Allergy and Infectious Diseases (NIAID) and National Institute of Biomedical Imaging and Bioengineering (NIBIB) brought together a group of experts (see Table 1) from these diverse fields for a workshop in September 2018 to: (1) engage the engineering, immunology, and HIV vaccinology communities to dialogue on the topic of an HIV vaccine and; (2) generate a framework of new and innovative research avenues to explore in HIV vaccinology between knowledge stakeholders and problem solvers.

Keywords: Adjuvants; Bioengineering; HIV vaccine; Immunology; Neutralizing antibodies.

MeSH terms

AIDS Vaccines / immunology*
Bioengineering*
Biomedical Research / organization & administration*
Cooperative Behavior
Drug Development
HIV Infections / prevention & control*
Humans
National Institute of Allergy and Infectious Diseases (U.S.)
National Institute of Biomedical Imaging and Bioengineering (U.S.)
United States
Vaccinology / organization & administration

Substances

AIDS Vaccines