Xeroderma pigmentosum group E cells lack a nuclear...[Science. 1988]

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1: Science. 1988 Oct 28;242(4878):564-7. Links

Xeroderma pigmentosum group E cells lack a nuclear factor that binds to damaged DNA.

Chu G, Chang E.

Department of Medicine, Stanford University School of Medicine, CA 94305.

The disease xeroderma pigmentosum is characterized by deficient repair of damaged DNA. Fusions of cells from different patients have defined nine genetic complementation groups (A through I), implying that DNA repair in humans involves multiple gene products. In this report, an extension of the gel electrophoresis binding assay was used to identify at least one nuclear factor that (i) bound to DNA damaged by ultraviolet radiation or the antitumor drug cisplatin, but (ii) was notably absent in cells from complementation group E. Therefore, the factor appears to participate in a versatile DNA repair pathway at the stage of binding and recognition.

PMID: 3175673 [PubMed - indexed for MEDLINE]

How cells recognize damaged DNA: clues from xeroderma pigmentosum and yeast.
Prog Clin Biol Res. 1990; 340A:275-82.

[Prog Clin Biol Res. 1990]
Xeroderma pigmentosum group E binding factor recognizes a broad spectrum of DNA damage.
Mutat Res. 1994 Oct 1; 310(1):89-102.

[Mutat Res. 1994]
Cisplatin-resistant cells express increased levels of a factor that recognizes damaged DNA.
Proc Natl Acad Sci U S A. 1990 May; 87(9):3324-7.

[Proc Natl Acad Sci U S A. 1990]
ReviewXeroderma pigmentosum complementation group E and UV-damaged DNA-binding protein.
DNA Repair (Amst). 2002 Aug 6; 1(8):601-16.

[DNA Repair (Amst). 2002]
ReviewXeroderma pigmentosum and molecular cloning of DNA repair genes.
Anticancer Res. 1996 Mar-Apr; 16(2):693-708.

[Anticancer Res. 1996]
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Arabidopsis DDB1-CUL4 ASSOCIATED FACTOR1 forms a nuclear E3 ubiquitin ligase with DDB1 and CUL4 that is involved in multiple plant developmental processes.
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Cisplatin (Platinol®-AQ)
Your doctor has ordered the drug cisplatin to help treat your illness. The drug is given by injection into a vein.
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Cited by 67 PubMed Central articles

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