Your browser version may not work well with NCBI's Web applications. More information here...
1: J Rheumatol. 1988 Jul;15(7):1166-70.Links

Coexistence of CREST syndrome and primary biliary cirrhosis. Serological studies of two cases.

Hirakata M, Akizuki M, Miyachi K, Matsushima H, Okano T, Homma M.

Department of Medicine, Keio University School of Medicine, Tokyo, Japan.

Two patients with characteristic features of CREST syndrome and primary biliary cirrhosis are reported. Sera of both patients contained autoantibodies to centromere and mitochondrial antigens. Immunodiffusion analysis identified the specificities of precipitating antibodies to mitochondria of the first case as anti-M-A and M-C, and of the second case as anti-M-A and M-B antibodies. Simultaneous occurrence of 2 marker antibodies in an individual patient indicates that the 2 patients reported here have CREST syndrome and primary biliary cirrhosis, both of which are considered as a distinct clinical entity.

PMID: 3172118 [PubMed - indexed for MEDLINE]