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Contraception. 1988 Jul;38(1):109-16.

Inhibition of pregnancy before and after implantation in rats with monoclonal antibody against progesterone.

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  • 1Ortho Research Laboratories, Ortho Pharmaceutical Corporation, Raritan, New Jersey 08869.


A monoclonal antibody against progesterone completely blocked pregnancy when rats were injected intraperitoneally at 0.53 mumol/kg/day on days 1 and 2, or on day 11 of a first pregnancy. The antibody was equally effective when injected again during a second pregnancy. There was no evidence for anti-idiotypic antibody production even when the injection of a heterologous (mouse) antibody was repeated in a second pregnancy.

[PubMed - indexed for MEDLINE]
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