Protective effects of a neurokinin 1 receptor antagonist on airway epithelial mitochondria dysfunction in asthmatic mice via Nrf2/HO-1 activation

Int Immunopharmacol. 2019 Dec:77:105952. doi: 10.1016/j.intimp.2019.105952. Epub 2019 Oct 31.

Authors

Zhijia Wang¹, Miao Li¹, Qianlan Zhou¹, Yunxiao Shang²

Affiliations

¹ Department of Paediatrics, Shengjing Hospital of China Medical University, Shenyang 110004, People's Republic of China.
² Department of Paediatrics, Shengjing Hospital of China Medical University, Shenyang 110004, People's Republic of China. Electronic address: shangyunxiao827@163.com.

PMID: 31677499
DOI: 10.1016/j.intimp.2019.105952

No abstract available

MeSH terms

Adenosine Triphosphate / metabolism
Androstenes / pharmacology
Androstenes / therapeutic use*
Animals
Asthma / drug therapy*
Benzimidazoles / pharmacology
Benzimidazoles / therapeutic use*
Bronchi / drug effects*
Bronchi / metabolism
Bronchi / ultrastructure
Cells, Cultured
Epithelium / drug effects
Epithelium / ultrastructure
Female
Heme Oxygenase-1 / physiology*
Humans
Interleukin-13 / pharmacology
Mice
Mice, Inbred BALB C
Mitochondria / drug effects*
Mitochondria / physiology
NF-E2-Related Factor 2 / physiology*
Neurokinin-1 Receptor Antagonists / therapeutic use*
Reactive Oxygen Species / metabolism
Trachea / drug effects
Trachea / metabolism
Trachea / pathology

Substances

Androstenes
Benzimidazoles
Interleukin-13
NF-E2-Related Factor 2
Neurokinin-1 Receptor Antagonists
Nfe2l2 protein, mouse
Reactive Oxygen Species
WIN 62577
Adenosine Triphosphate
Heme Oxygenase-1