The Dual Role of Kinin/Kinin Receptors System in Alzheimer's Disease

Bingyuan Ji; Qinqin Wang; Qingjie Xue; Wenfu Li; Xuezhi Li; Yili Wu

doi:10.3389/fnmol.2019.00234

The Dual Role of Kinin/Kinin Receptors System in Alzheimer's Disease

Front Mol Neurosci. 2019 Oct 1:12:234. doi: 10.3389/fnmol.2019.00234. eCollection 2019.

Authors

Bingyuan Ji¹, Qinqin Wang¹, Qingjie Xue², Wenfu Li¹, Xuezhi Li^{3

4}, Yili Wu^{3

4}

Affiliations

¹ Neurobiology Institute, School of Mental Health, Jining Medical University, Jining, China.
² Department of Pathogenic Biology, Jining Medical University, Jining, China.
³ Shandong Collaborative Innovation Center for Diagnosis, Treatment and Behavioral Interventions of Mental Disorders, Institute of Mental Health, Jining Medical University, Jining, China.
⁴ Shandong Key Laboratory of Behavioral Medicine, School of Mental Health, Jining Medical University, Jining, China.

Abstract

Alzheimer's disease (AD) is the most common neurodegenerative disease characterized by progressive spatial disorientation, learning and memory deficits, responsible for 60%-80% of all dementias. However, the pathological mechanism of AD remains unknown. Numerous studies revealed that kinin/kinin receptors system (KKS) may be involved in the pathophysiology of AD. In this review article, we summarized the roles of KKS in neuroinflammation, cerebrovascular impairment, tau phosphorylation, and amyloid β (Aβ) generation in AD. Moreover, we provide new insights into the mechanistic link between KKS and AD, and highlight the KKS as a potential therapeutic target for AD treatment.

Keywords: Alzheimer’s disease; amyloid beta; kinins receptors; neuroinflammation; neuroprotection.