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Structural gene encoding human factor XII is located at 5q33-qter.
Department of Human Genetics, University of Manitoba, Canada.
The gene encoding human factor XII (F12) or Hageman factor has been mapped to 5q33-qter. This has been achieved by analyzing the results obtained from hybridizing a cloned fragment from the factor XII gene to a panel of human-hamster somatic cell hybrid DNAs and also by in situ hybridization to normal human metaphase cells. The previously reported results localizing F12 to 6p23 are discussed.
PMID: 3162339 [PubMed - indexed for MEDLINE]
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Cited by 1 PubMed Central article
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A quantitative-trait locus in the human factor XII gene influences both plasma factor XII levels and susceptibility to thrombotic disease.
Soria JM, Almasy L, Souto JC, Bacq D, Buil A, Faure A, Martínez-Marchán E, Mateo J, Borrell M, Stone W, et al.
Am J Hum Genet. 2002 Mar; 70(3):567-74. Epub 2002 Jan 22.
[Am J Hum Genet. 2002]