Selenosulfides Tethered to gem-Dimethyl Esters: A Robust and Highly Versatile Framework for H2 S Probe Development

S Israel Suarez; Rynne Ambrose; Madison A Kalk; John C Lukesh 3rd

doi:10.1002/chem.201904133

Selenosulfides Tethered to gem-Dimethyl Esters: A Robust and Highly Versatile Framework for H₂ S Probe Development

Chemistry. 2019 Dec 10;25(69):15736-15740. doi: 10.1002/chem.201904133. Epub 2019 Oct 31.

Authors

S Israel Suarez¹, Rynne Ambrose¹, Madison A Kalk¹, John C Lukesh 3rd¹

Affiliation

¹ Department of Chemistry, Wake Forest University, Wake Downtown Campus, Winston-Salem, NC, 27101, USA.

PMID: 31576582
DOI: 10.1002/chem.201904133

Abstract

Selenosulfides coupled to gem-dimethyl esters provide an exceptional platform for H₂ S probe development. With the sulfur half being nonessential to its high reactivity and selectivity towards H₂ S, we highlight the unique flexibility of our design by improving its biocompatibility and tissue specificity through structural modifications of its sulfide moiety.

Keywords: H2S; chemical probes; selenium chemistry; selenosulfides.

Grants and funding

Wake Forest University