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Arch Biol Med Exp (Santiago). 1988 Jun;21(1):165-9.

A rapid decline in external Ca2+ induces Ca2+ mobilization in bovine adrenal glomerulosa cells.

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  • 1Departamento de Fisiología y Biofísica, Facultad de Medicina, Universidad de Chile, Santiago.


Bovine adrenal glomerulosa cells perifused with M 199 containing 1 mM Ca2+ showed a transient increase in 45Ca2+ when the external Ca2+ was decreased. The efflux observed in the presence of 100 nM angiotensin II was similar to that observed when the external Ca2+ was changed from 1 mM to 50 microM. This efflux is the result of the transient activation of the PIP2 hydrolysis with the subsequent production of inositol-trisphosphate.

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