The present study was undertaken to determine the current status of Schistosoma japonicum infection in the newly found endemic focus at Hanpao Farm, Fangyuan District, Changhua County, West-Central Taiwan. Two field surveys and one laboratory investigation were conducted from July to October 1987. Of 705 snails examined by shedding and crushing methods, 17.0% were found to harbor cercariae of S. japonicum. By sodium sulfate-acid-ether-triton centrifugal sedimentation technique, 25% of 16 cattle, 40% of 5 goats, and 50% of 4 dogs were found to be positive for S. japonicum eggs. In the laboratory, 21 mice were exposed to cercariae from single naturally infected snails. Following inoculation, 7 mice died early, 7 were found infected with male worms, 2 with female worms, and 1 with bisexual infection. The results of the present study indicated that the infection rates of snails and domestic animals are higher than those previously reported from elsewhere in Changhua County.