Extracellular matrix-based scaffolding technologies for periodontal and peri-implant soft tissue regeneration

Lorenzo Tavelli; Michael K McGuire; Giovanni Zucchelli; Giulio Rasperini; Stephen E Feinberg; Hom-Lay Wang; William V Giannobile

doi:10.1002/JPER.19-0351

Extracellular matrix-based scaffolding technologies for periodontal and peri-implant soft tissue regeneration

J Periodontol. 2020 Jan;91(1):17-25. doi: 10.1002/JPER.19-0351. Epub 2019 Sep 19.

Authors

Lorenzo Tavelli¹, Michael K McGuire^{1

2

3}, Giovanni Zucchelli^{1

4}, Giulio Rasperini^{1

5}, Stephen E Feinberg⁶, Hom-Lay Wang¹, William V Giannobile^{1

7}

Affiliations

¹ Department of Periodontics & Oral Medicine, University of Michigan, School of Dentistry, Ann Arbor, MI, USA.
² Private practice, Houston, TX, USA.
³ Department of Periodontics, University of Texas, Dental Branch Houston and Health Science Center, San Antonio, TX, USA.
⁴ Department of Biomedical and Neuromotor Sciences, University of Bologna, Bologna, Italy.
⁵ Department of Biomedical, Surgical and Dental Sciences, University of Milan, Foundation IRCCS Ca' Granda Policlinic, Milan, Italy.
⁶ Department of Oral and Maxillofacial Surgery, University of Michigan, Ann Arbor, MI, USA.
⁷ Department of Biomedical Engineering & Biointerfaces Institute, College of Engineering, University of Michigan, Ann Arbor, MI, USA.

PMID: 31475361
DOI: 10.1002/JPER.19-0351

Abstract

The present article focuses on the properties and indications of scaffold-based extracellular matrix (ECM) technologies as alternatives to autogenous soft tissue grafts for periodontal and peri-implant plastic surgical reconstruction. The different processing methods for the creation of cell-free constructs resulting in preservation of the extracellular matrices influence the characteristics and behavior of scaffolding biomaterials. The aim of this review is to discuss the properties, clinical application, and limitations of ECM-based scaffold technologies in periodontal and peri-implant soft tissue augmentation when used as alternatives to autogenous soft tissue grafts.

Keywords: acellular dermal graft; collagen matrix; dental implant; gingival recession; soft tissue augmentation; soft tissue volume.

Publication types

Research Support, Non-U.S. Gov't
Review

MeSH terms

Biocompatible Materials
Extracellular Matrix
Gingiva*
Plastic Surgery Procedures*
Wound Healing

Substances

Biocompatible Materials