J Nutr. 1988 Nov;118(11):1278-89.

Measurement of energy expenditure in free-living humans by using doubly labeled water.

Source

Clinical Nutrition Research Center, University of Chicago, IL 60637.

Abstract

The doubly labeled water method is a form of indirect calorimetry that has been developed only recently to the stage of application to human studies. The method measures integral CO2 production for up to 3 wk from the difference in elimination rates of deuterium and 18O from labeled body water. Validations against near-continuous respiratory gas exchange have demonstrated that the method is accurate and has a precision of 2-8% depending on the isotope dose and the length of the elimination period. Although the method has been validated, there is still some debate on refinements of the kinetic model that may lead to improved accuracy and precision. Because the method only requires periodic sampling of body fluids, it is non-restrictive and ideally suited to use in free-living subjects. Recent applications of the method have included obesity research, determination of energy requirements in both developing and developed countries and studies of human growth.

PMID:: 3142975; [PubMed - indexed for MEDLINE]

Free full text

Publication Types, MeSH Terms, Substances, Grant Support

Publication Types

MeSH Terms

Substances

Grant Support

LinkOut - more resources

Full Text Sources

HighWire Press - PDF

Molecular Biology Databases

Supplemental Content

Save items

Related citations in PubMed

Review Analytic requirements for the doubly labeled water method. [Obes Res. 1995]
Review Analytic requirements for the doubly labeled water method.
Schoeller DA, Taylor PB, Shay K. Obes Res. 1995 Mar; 3 Suppl 1:15-20.
Energy expenditure by doubly labeled water: validation in lean and obese subjects. [Am J Physiol. 1991]
Energy expenditure by doubly labeled water: validation in lean and obese subjects.
Ravussin E, Harper IT, Rising R, Bogardus C. Am J Physiol. 1991 Sep; 261(3 Pt 1):E402-9.
Calorimetric validation of the doubly-labelled water method for determination of energy expenditure in man. [Hum Nutr Clin Nutr. 1984]
Calorimetric validation of the doubly-labelled water method for determination of energy expenditure in man.
Klein PD, James WP, Wong WW, Irving CS, Murgatroyd PR, Cabrera M, Dallosso HM, Klein ER, Nichols BL. Hum Nutr Clin Nutr. 1984 Mar; 38(2):95-106.
Multiple laboratory comparison of the doubly labeled water technique. [Obes Res. 1995]
Multiple laboratory comparison of the doubly labeled water technique.
Roberts SB, Dietz W, Sharp T, Dallal GE, Hill JO. Obes Res. 1995 Mar; 3 Suppl 1:3-13.
Review Use of the doubly labeled water method for measurement of energy expenditure, total body water, water intake, and metabolizable energy intake in humans and small animals. [Can J Physiol Pharmacol. 1989]
Review Use of the doubly labeled water method for measurement of energy expenditure, total body water, water intake, and metabolizable energy intake in humans and small animals.
Roberts SB. Can J Physiol Pharmacol. 1989 Oct; 67(10):1190-8.

See reviews... See all...

Cited by 21 PubMed Central articles

Feasibility testing of an automated image-capture method to aid dietary recall. [Eur J Clin Nutr. 2011]
Feasibility testing of an automated image-capture method to aid dietary recall.
Arab L, Estrin D, Kim DH, Burke J, Goldman J. Eur J Clin Nutr. 2011 Oct; 65(10):1156-62. Epub 2011 May 18.
Development of adherence metrics for caloric restriction interventions. [Clin Trials. 2011]
Development of adherence metrics for caloric restriction interventions.
Pieper C, Redman L, Racette S, Roberts S, Bhapkar M, Rochon J, Martin C, Kraus W, Das S, Williamson D, et al. Clin Trials. 2011 Apr; 8(2):155-64. Epub 2011 Mar 8.
Review Objectively measured physical activity and fat mass in children: a bias-adjusted meta-analysis of prospective studies. [PLoS One. 2011]
Review Objectively measured physical activity and fat mass in children: a bias-adjusted meta-analysis of prospective studies.
Wilks DC, Sharp SJ, Ekelund U, Thompson SG, Mander AP, Turner RM, Jebb SA, Lindroos AK. PLoS One. 2011 Feb 23; 6(2):e17205. Epub 2011 Feb 23.

See all...

Related information

Related Citations
Calculated set of PubMed citations closely related to the selected article(s) retrieved using a word weight algorithm. Related articles are displayed in ranked order from most to least relevant, with the “linked from” citation displayed first.
Compound (MeSH Keyword)
PubChem chemical compound records that are classified under the same Medical Subject Headings (MeSH) controlled vocabulary as the current articles.
Substance (MeSH Keyword)
PubChem chemical substance (submitted) records that are classified under the same Medical Subject Headings (MeSH) controlled vocabulary as the current articles.
Cited in PMC
Full-text articles in the PubMed Central Database that cite the current articles.

Recent activity

Clear Turn Off Turn On

Measurement of energy expenditure in free-living humans by using doubly labeled ...
Measurement of energy expenditure in free-living humans by using doubly labeled water.
J Nutr. 1988 Nov ;118(11):1278-89.

PubMed
The presence of a reduced amount of 32-kd "protective" protein is a distinct bio...
The presence of a reduced amount of 32-kd "protective" protein is a distinct biochemical finding in late infantile galactosialidosis.
Hum Genet. 1988 Nov ;80(3):304-6.

PubMed
Doctors' drinking habits and consumption of alcohol.
Doctors' drinking habits and consumption of alcohol.
BMJ. 1988 Oct 15 ;297(6654):951-4.

PubMed
Arteriovenous malformation of the stomach.
Arteriovenous malformation of the stomach.
Am J Gastroenterol. 1979 Aug ;72(2):160-4.

PubMed
Urinary tract morbidity in schistosomiasis haematobia: associations with age and...
Urinary tract morbidity in schistosomiasis haematobia: associations with age and intensity of infection in an endemic area of Coast Province, Kenya.
Am J Trop Med Hyg. 1988 Oct ;39(4):361-8.

PubMed

Your browsing activity is empty.

Activity recording is turned off.

Turn recording back on

PubMed

Result Filters

Display Settings:

Send to: