Br Heart J. 1988 Sep;60(3):247-51.

Familial neurofibromatosis and hypertrophic cardiomyopathy.

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Cardiac Department, Westminster Hospital, London.

Abstract

Two siblings from a family in which neurofibromatosis was inherited as an autosomal dominant had hypertrophic cardiomyopathy and neurofibromatosis. Idiopathic hypertrophic cardiomyopathy may have occurred by chance in two first degree relatives with neurofibromatosis. An alternative explantation is that these diseases are both manifestations of a common hereditary defect of neural crest tissue. Another possibility is that abnormalities of catecholamine metabolism and nerve growth factor in neurofibromatosis can cause secondary ventricular hypertrophy with septal involvement.

PMID:: 3140859; [PubMed - indexed for MEDLINE]
PMCID:: PMC1216562

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[Familial neurofibromatosis and hypertrophic obstructive cardiomyopathy]. [Ugeskr Laeger. 1991]
[Familial neurofibromatosis and hypertrophic obstructive cardiomyopathy].
Pedersen OD, Bagger H. Ugeskr Laeger. 1991 Dec 30; 154(1):26-7.
Idiopathic hypertrophic subaortic stenosis associated with cutaneous neurofibromatosis: report of a case. [Am Heart J. 1976]
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[Regressive hypertrophic myocardiopathy in an infant with Recklinghausen's neurofibromatosis]. [Arch Fr Pediatr. 1986]
[Regressive hypertrophic myocardiopathy in an infant with Recklinghausen's neurofibromatosis].
Tillous-Borde I, Challier P, Fontaine JL. Arch Fr Pediatr. 1986 Mar; 43(3):197-200.
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Review Molecular basis of hypertrophic and dilated cardiomyopathy.
Marian AJ, Roberts R. Tex Heart Inst J. 1994; 21(1):6-15.
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Review Neurofibromatosis and Albright's syndrome.
Riccardi VM. Dermatol Clin. 1987 Jan; 5(1):193-203.

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Cited by 1 PubMed Central article

Cardiomyocyte-specific loss of neurofibromin promotes cardiac hypertrophy and dysfunction. [Circ Res. 2009]
Cardiomyocyte-specific loss of neurofibromin promotes cardiac hypertrophy and dysfunction.
Xu J, Ismat FA, Wang T, Lu MM, Antonucci N, Epstein JA. Circ Res. 2009 Jul 31; 105(3):304-11. Epub 2009 Jul 2.

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