Display Settings:


Send to:

Choose Destination
See comment in PubMed Commons below
Am J Physiol. 1988 Oct;255(4 Pt 2):R569-74.

Capsaicin attenuates suppression of sham feeding induced by intestinal nutrients.

Author information

  • 1Department of Veterinary and Comparative Anatomy, Pharmacology, and Physiology, College of Veterinary Medicine, Washington State University, Pullman 99164.


Satiety appears to be mediated in part by neurally transmitted signals from the gastrointestinal tract. Capsaicin is a neurotoxin that selectively destroys small unmyelinated primary sensory neurons including some of those innervating the abdominal viscera. Therefore, we examined suppression of sham feeding induced by cholecystokinin octapeptide (CCK-8) or intraintestinal nutrient infusions in capsaicin-treated rats. Suppression of sham feeding induced by CCK-8 was significantly attenuated in rats treated with capsaicin. Suppression of sham feeding induced by intraintestinal infusions of maltose, oleic acid, or L-phenylalanine was also attenuated in capsaicin-treated rats. In contrast, capsaicin treatment did not attenuate the suppression of sham feeding induced by intraintestinal casein hydrolysate (mixed amino acids). Intraintestinal infusions of octanoic acid or D-phenylalanine solutions did not significantly suppress sham feeding in either vehicle- or capsaicin-treated rats. These results indicate that the suppression of feeding by some intestinal stimuli may be mediated by nutrient or peptide-sensitive visceral afferent neurons that are sensitive to damage or destruction by capsaicin.

[PubMed - indexed for MEDLINE]
PubMed Commons home

PubMed Commons

How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for HighWire
    Loading ...
    Write to the Help Desk