Abstract
Centromeres are the structural elements of eukaryotic chromosomes that hold sister chromatids together and to which spindle tubules connect during cell division. Centromeres have been shown to suppress meiotic recombination in some systems. In this study yeast strains genetically marked within and flanking a centromere, were used to demonstrate that gene conversion (nonreciprocal recombination) tracts in mitosis can enter into and extend through the centromere.
Publication types
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Alleles
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Centromere / metabolism*
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Chromosomes / metabolism*
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Crossing Over, Genetic
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Gene Conversion
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Genes, Fungal
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Histidine / metabolism
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Leucine / metabolism
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Mitosis*
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Mutation
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Recombination, Genetic*
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Saccharomyces cerevisiae / genetics*
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Saccharomyces cerevisiae / growth & development
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Threonine / metabolism
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Trichodermin / pharmacology
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Uracil / metabolism
Substances
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Threonine
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Trichodermin
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Histidine
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Uracil
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Leucine