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Cloning and expression of the human interleukin-6 (BSF-2/IFN beta 2) receptor.
Division of Immunology, Osaka University, Japan.
Interleukin-6 (IL-6/BSF-2/IFN beta 2) is a multifunctional cytokine that regulates the growth and differentiation of various tissues, and is known particularly for its role in the immune response and acute phase reactions. A complementary DNA encoding the human IL-6 receptor (IL-6-R) has now been isolated. The IL-6-R consists of 468 amino acids, including a signal peptide of approximately 19 amino acids and a domain of approximately 90 amino acids that is similar to a domain in the immunoglobulin (Ig) superfamily. The cytoplasmic domain of approximately 82 amino acids lacks a tyrosine/kinase domain, unlike other growth factor receptors.
PMID: 3136546 [PubMed - indexed for MEDLINE]
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Cited by over 100 PubMed Central articles
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ReviewInterleukin-6 in aging and chronic disease: a magnificent pathway.
Maggio M, Guralnik JM, Longo DL, Ferrucci L.
J Gerontol A Biol Sci Med Sci. 2006 Jun; 61(6):575-84.
[J Gerontol A Biol Sci Med Sci. 2006]
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Dynamics of the gp130 cytokine complex: a model for assembly on the cellular membrane.
Schroers A, Hecht O, Kallen KJ, Pachta M, Rose-John S, Grötzinger J.
Protein Sci. 2005 Mar; 14(3):783-90.
[Protein Sci. 2005]
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Neutrophils alter the inflammatory milieu by signal-dependent translation of constitutive messenger RNAs.
Lindemann SW, Yost CC, Denis MM, McIntyre TM, Weyrich AS, Zimmerman GA.
Proc Natl Acad Sci U S A. 2004 May 4; 101(18):7076-81. Epub 2004 Apr 26.
[Proc Natl Acad Sci U S A. 2004]
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