Mucopenetrating lipoplexes modified with PEG and hyaluronic acid for CD44-targeted local siRNA delivery to the lungs

J Biomater Appl. 2019 Nov;34(5):617-630. doi: 10.1177/0885328219863291. Epub 2019 Jul 29.
No abstract available

Keywords: Polyethylene glycol; gene therapy; liposomes; mucus; pulmonary administration.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • A549 Cells
  • Administration, Inhalation
  • Animals
  • Cell Membrane Permeability
  • Female
  • Genetic Therapy
  • Humans
  • Hyaluronan Receptors / metabolism*
  • Hyaluronic Acid / chemistry*
  • Liposomes / chemistry*
  • Liposomes / metabolism
  • Lung / metabolism
  • Mice
  • Mucus / metabolism*
  • Phosphatidylethanolamines / chemistry*
  • Polyethylene Glycols / chemistry*
  • RNA, Small Interfering / administration & dosage
  • RNA, Small Interfering / chemistry*
  • Surface Properties
  • Tissue Distribution
  • Transfection

Substances

  • Hyaluronan Receptors
  • Liposomes
  • Phosphatidylethanolamines
  • RNA, Small Interfering
  • Polyethylene Glycols
  • 1,2-dielaidoylphosphatidylethanolamine
  • Hyaluronic Acid