Mouse Watch: A Cautionary Tale

Immunity. 2019 Jul 16;51(1):10-12. doi: 10.1016/j.immuni.2019.06.019.

Abstract

In this issue of Immunity, Chisolm et al. (2019) issue a "three-alarm fire" warning to the immunology research community of unexpectedly widespread genetic variation in widely used congenic mouse strains and provide a simple method to identify such a variation through a re-analysis of existing RNA-seq and ChIP-seq datasets.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Comment

MeSH terms

  • Animals
  • Chromatin Immunoprecipitation
  • DNA Mutational Analysis
  • Genetic Variation*
  • Mice