Antibacterial treatment of otitis and sinusitis wi...[Infection. 1988]

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1: Infection. 1988;16 Suppl 1:S51-4.Links

Antibacterial treatment of otitis and sinusitis with ciprofloxacin and penicillin V--a comparison.

Falser N, Mittermayer H, Weuta H.

Universitätsklinik für Hals-, Nasen- und Ohrenkrankheiten, Innsbruck.

80 adult outpatients suffering from otitis media, sinusitis (maxillaris or frontalis) or peritonsillitis were treated with 500 mg ciprofloxacin b.i.d. (n = 40) or with 2 g penicillin V t.i.d. (n = 40). The patients were randomly allocated. Three groups of patients resulted, clinically and bacteriologically evaluable, or only clinically evaluable because the isolated strains were resistant to ciprofloxacin or penicillin V or because no strains were isolated. Ciprofloxacin was superior to penicillin V; there were fewer resistant strains (one compared to 11), and the eradication rate (57% compared to 43%) as well as the clinical efficacy (60% compared to 48%) of ciprofloxacin were better than those of penicillin V--even in a daily dose of 6.0 g. Both treatments were well tolerated; side effects were neither reported nor found.

PMID: 3131251 [PubMed - indexed for MEDLINE]

Comparison of penicillin and trimethoprim-sulfamethoxazole in the treatment of ear, nose and throat infections. [Can Med Assoc J. 1975]
Trimethoprim-sulfamethoxazole in the treatment of infections of the ears, nose, and throat. [J Infect Dis. 1973]
Comparison of azithromycin versus clarithromycin in the treatment of patients with upper respiratory tract infections. [J Antimicrob Chemother. 1993]
ReviewCurrent issues in upper respiratory tract infections in infants and children: rationale for antibacterial therapy. [Pediatr Infect Dis J. 1994]
ReviewLevofloxacin: a review of its use in the treatment of bacterial infections in the United States. [Drugs. 2003]

Patient Drug Information

Ciprofloxacin (Cipro®, Cipro® XR, Proquin® XR) Pending revision, the material in this section should be considered in light of more recently available information in the MedWatch notification at the beginning of this monograph.

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Antibacterial treatment of otitis and sinusitis with ciprofloxacin and penicillin V--a comparison.

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