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Nature. 1988 Mar 24;332(6162):323-7.

Reshaping human antibodies for therapy.

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  • 1MRC Laboratory of Molecular Biology, Cambridge, UK.


A human IgGI antibody has been reshaped for serotherapy in humans by introducing the six hypervariable regions from the heavy- and light-chain variable domains of a rat antibody directed against human lymphocytes. The reshaped human antibody is as effective as the rat antibody in complement and is more effective in cell-mediated lysis of human lymphocytes.

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