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    Nature. 1988 Mar 24;332(6162):323-7.

    Reshaping human antibodies for therapy.

    Riechmann L, Clark M, Waldmann H, Winter G.

    MRC Laboratory of Molecular Biology, Cambridge, UK.

    A human IgGI antibody has been reshaped for serotherapy in humans by introducing the six hypervariable regions from the heavy- and light-chain variable domains of a rat antibody directed against human lymphocytes. The reshaped human antibody is as effective as the rat antibody in complement and is more effective in cell-mediated lysis of human lymphocytes.

    PMID: 3127726 [PubMed - indexed for MEDLINE]

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