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Reshaping human antibodies for therapy.
MRC Laboratory of Molecular Biology, Cambridge, UK.
A human IgGI antibody has been reshaped for serotherapy in humans by introducing the six hypervariable regions from the heavy- and light-chain variable domains of a rat antibody directed against human lymphocytes. The reshaped human antibody is as effective as the rat antibody in complement and is more effective in cell-mediated lysis of human lymphocytes.
PMID: 3127726 [PubMed - indexed for MEDLINE]
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Cited by 74 PubMed Central articles
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Alteration of enzyme specificity by computational loop remodeling and design.
Murphy PM, Bolduc JM, Gallaher JL, Stoddard BL, Baker D.
Proc Natl Acad Sci U S A. 2009 Jun 9; 106(23):9215-20. Epub 2009 May 21.
[Proc Natl Acad Sci U S A. 2009]
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Targeting of natural killer cells by rabbit antithymocyte globulin and campath-1H: similar effects independent of specificity.
Stauch D, Dernier A, Sarmiento Marchese E, Kunert K, Volk HD, Pratschke J, Kotsch K.
PLoS One. 2009; 4(3):e4709. Epub 2009 Mar 5.
[PLoS One. 2009]
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Recent advances in the generation of human monoclonal antibody.
Yamashita M, Katakura Y, Shirahata S.
Cytotechnology. 2007 Dec; 55(2-3):55-60. Epub 2007 Apr 21.
[Cytotechnology. 2007]
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