What is known and objective: Reveal the current status of grapefruit in the Chinese medical environment.
Case description: An approximately 2-fold increase in blood tacrolimus concentration was observed on day 9 in the hospital despite no change in dose. The only possible cause is that the patient had consumed grapefruit during hospitalization, which is often mistakenly considered to be a fruit belonging to the West and uncommon in the medical environment in China.
What is new and conclusion: This is the first report of grapefruit-induced blood tacrolimus concentration change. Chinese medical practitioners should re-evaluate the impact of grapefruit and food-drug interactions caused by it.
Keywords: Grapefruit; food-drug interaction; renal transplantation; tacrolimus.
© 2019 John Wiley & Sons Ltd.