Am J Med. 1987 Nov 20;83(5A):48-54.

Effects of S-adenosylmethionine on human articular chondrocyte differentiation. An in vitro study.

Harmand MF, Vilamitjana J, Maloche E, Duphil R, Ducassou D.

Source

Inserm U. 306, Université de Bordeaux II, France.

Abstract

The effect of S-adenosyl-L-methionine (SAMe) on human articular osteoarthritic chondrocytes was studied using a thick-layer culture model. Three SAMe concentrations were tested (1, 10, and 100 micrograms/ml). For 10 micrograms/ml, the most efficient dose, a significant rise in the incorporation levels of 35S-sulfate and 3H-serine was observed, as was as an increase in the hexuronic acid content. All the parameters seem to express a more active protein synthesis, particularly for proteoglycans. Under the same conditions, the proliferation rate of chondrocytes does not undergo important variations. These results point to a direct action on the cell metabolism but little is known concerning the mechanism involved.

PMID:: 3120586; [PubMed - indexed for MEDLINE]

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Cited by 2 PubMed Central articles

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Park YS, Lim SW, Lee IH, Lee TJ, Kim JS, Han JS. Arthritis Res Ther. 2007; 9(1):R8.
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Chemical compound information

S-Adenosylmethionine

MW: 398.43 g/mol

MF: C₁₅H₂₂N₆O₅S

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