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Cell Immunol. 1987 Oct 1;109(1):159-68.

Lymphokines induce specificity degradation in virus-induced cytolytic T-cell clones.

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  • 1Laboratory of Infectious Diseases, Dana Farber Cancer Institute, Boston, Massachusetts.


The target cell specificity of antiviral cytolytic T-lymphocyte (CTL) clones is influenced by in vitro tissue culture conditions. We have demonstrated that high concentrations of lymphokines such as recombinant interleukin-2 (rIL-2) induce killer T cells to lose virus specificity. Our experiments do not indicate that the cells become like natural killer (NK) cells. The loss of specificity is more general and can be reversed upon culture in more physiological concentrations of lymphokines. The implications of these observations for the pathogenesis of viral infection is discussed.

[PubMed - indexed for MEDLINE]
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