Format

Send to

Choose Destination
See comment in PubMed Commons below
Cell. 1987 Oct 9;51(1):51-7.

Occupation of the extracellular matrix receptor, integrin, is a control point for myogenic differentiation.

Author information

  • 1Department of Microbiology, University of Pennsylvania, Philadelphia 19104.

Abstract

Replicating chicken embryo myoblasts were treated with a monoclonal antibody, CSAT, which recognizes and blocks the function of the beta subunit of integrin. In the presence of this antibody, myoblasts continued to replicate and did not fuse or produce muscle-specific meromyosin. This block to normal differentiation was readily reversed by the removal of the antibody. The reversed cells exhibited increases in desmin and meromyosin, and fused to produce contracting myotubes. The data indicate that the interaction of integrin, present on the membrane of replicating myoblasts, with extracellular matrix on the substrate is essential to initiate the terminal stages of myogenic differentiation.

PMID:
3115595
[PubMed - indexed for MEDLINE]

LinkOut - more resources

Full Text Sources

Other Literature Sources

PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Elsevier Science
    Loading ...
    Write to the Help Desk