Fecal Immunoglobulin A Against a Sporozoite Antigen at 12 Months Is Associated With Delayed Time to Subsequent Cryptosporidiosis in Urban Bangladesh: A Prospective Cohort Study

Clin Infect Dis. 2020 Jan 2;70(2):323-326. doi: 10.1093/cid/ciz430.

Abstract

In this prospective cohort study of Bangladeshi children, greater fecal immunoglobulin A, but not plasma immunoglobulin G, directed against the Cryptosporidium sporozoite-expressed antigen Cp23 at 12 months of age was associated with delayed time to subsequent cryptosporidiosis. This finding suggests a protective role for mucosal antibody-mediated immunity in naturally exposed children.

Keywords: Cp23; IgA; cryptosporidiosis; fecal; mucosal.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Antibodies, Protozoan
  • Bangladesh / epidemiology
  • Child
  • Cryptosporidiosis* / diagnosis
  • Cryptosporidiosis* / epidemiology
  • Cryptosporidium*
  • Humans
  • Immunoglobulin A
  • Prospective Studies
  • Sporozoites

Substances

  • Antibodies, Protozoan
  • Immunoglobulin A