Manganese(iii)-chelated porphyrin microbubbles for enhanced ultrasound/MR bimodal tumor imaging through ultrasound-mediated micro-to-nano conversion

Min Chen; Xiaolong Liang; Zhifei Dai

doi:10.1039/c9nr01373c

Manganese(iii)-chelated porphyrin microbubbles for enhanced ultrasound/MR bimodal tumor imaging through ultrasound-mediated micro-to-nano conversion

Nanoscale. 2019 May 30;11(21):10178-10182. doi: 10.1039/c9nr01373c.

Authors

Min Chen¹, Xiaolong Liang, Zhifei Dai

Affiliation

¹ Department of Biomedical Engineering, College of Engineering, Peking University, Beijing 100871, People's Republic of China. zhifei.dai@pku.edu.cn.

PMID: 31111845
DOI: 10.1039/c9nr01373c

Abstract

Manganese(iii)-chelated porphyrin microbubbles (MnP-MBs) were fabricated by self-assembly from a Mn-chelated porphyrin lipid followed by encapsulating perfluoropropane-an inert gas. The obtained MnP-MBs exhibited enhanced ultrasound imaging ability after intravenous injection. Under the guidance of ultrasound imaging, MnP-MBs could be converted into nanoparticles in situ with local tumor ultrasound disruption, achieving rapid tumor MRI contrast enhancement within 30 min at a very low Mn injection dose of 0.09 mg (1.65 μmol) per kg.

MeSH terms

Animals
Cell Line, Tumor
Chelating Agents / chemistry
Chelating Agents / pharmacology
Contrast Media* / chemistry
Contrast Media* / pharmacology
Hematoporphyrins* / chemistry
Hematoporphyrins* / pharmacology
Humans
Magnetic Resonance Imaging*
Metalloporphyrins* / chemistry
Metalloporphyrins* / pharmacology
Mice
Mice, Nude
Microbubbles*
Neoplasms, Experimental / diagnostic imaging*
Neoplasms, Experimental / metabolism
Neoplasms, Experimental / pathology
Ultrasonic Waves*
Ultrasonography

Substances

Chelating Agents
Contrast Media
Hematoporphyrins
Metalloporphyrins
manganese (III) hematoporphyrin