Abstract
Manganese(iii)-chelated porphyrin microbubbles (MnP-MBs) were fabricated by self-assembly from a Mn-chelated porphyrin lipid followed by encapsulating perfluoropropane-an inert gas. The obtained MnP-MBs exhibited enhanced ultrasound imaging ability after intravenous injection. Under the guidance of ultrasound imaging, MnP-MBs could be converted into nanoparticles in situ with local tumor ultrasound disruption, achieving rapid tumor MRI contrast enhancement within 30 min at a very low Mn injection dose of 0.09 mg (1.65 μmol) per kg.
MeSH terms
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Animals
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Cell Line, Tumor
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Chelating Agents / chemistry
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Chelating Agents / pharmacology
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Contrast Media* / chemistry
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Contrast Media* / pharmacology
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Hematoporphyrins* / chemistry
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Hematoporphyrins* / pharmacology
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Humans
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Magnetic Resonance Imaging*
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Metalloporphyrins* / chemistry
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Metalloporphyrins* / pharmacology
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Mice
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Mice, Nude
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Microbubbles*
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Neoplasms, Experimental / diagnostic imaging*
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Neoplasms, Experimental / metabolism
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Neoplasms, Experimental / pathology
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Ultrasonic Waves*
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Ultrasonography
Substances
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Chelating Agents
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Contrast Media
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Hematoporphyrins
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Metalloporphyrins
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manganese (III) hematoporphyrin