Hidden Figures: A Non-translated RNA Regulates Axonal Neurotrophin Signaling

Nicolas Panayotis; Mike Fainzilber

doi:10.1016/j.neuron.2019.04.019

Hidden Figures: A Non-translated RNA Regulates Axonal Neurotrophin Signaling

Neuron. 2019 May 8;102(3):507-509. doi: 10.1016/j.neuron.2019.04.019.

Authors

Nicolas Panayotis¹, Mike Fainzilber²

Affiliations

¹ Department of Biomolecular Sciences, Weizmann Institute of Science, Rehovot 7610001, Israel.
² Department of Biomolecular Sciences, Weizmann Institute of Science, Rehovot 7610001, Israel. Electronic address: mike.fainzilber@weizmann.ac.il.

PMID: 31071280
DOI: 10.1016/j.neuron.2019.04.019

Abstract

In this issue of Neuron, Crerar et al. (2019) found Tp53inp2 as a highly expressed RNA in sympathetic neuron axons. Strikingly, its long 3' UTR ensures that Tp53inp2 is not translated in axons, and the untranslated RNA affects neuronal growth by interacting with neurotrophin receptors.

Publication types

Comment

MeSH terms

Axons
Nerve Growth Factor*
RNA*
RNA, Messenger
Signal Transduction

Substances

RNA, Messenger
RNA
Nerve Growth Factor