Br J Rheumatol. 1987 Apr;26(2):103-7.

Increased intestinal permeability in patients with rheumatoid arthritis: a side-effect of oral nonsteroidal anti-inflammatory drug therapy?

Jenkins RT, Rooney PJ, Jones DB, Bienenstock J, Goodacre RL.

Abstract

Intestinal permeability in controls and in patients with active rheumatoid arthritis was assessed by measuring the radioactivity in 24-h urine collections after oral administration of 51Cr-EDTA. Intestinal permeability in the patients was found to be significantly increased in comparison to controls. Of the patients, 6/7 (86%) not taking any prescribed nonsteroidal anti-inflammatory drug (NSAID) at the time of study had normal results, whereas 23/29 patients (79%) taking prescribed NSAIDs displayed increased intestinal permeability. It has not been determined beyond doubt whether this finding is due to disease process or therapy with oral NSAIDs.

PMID:: 3103807; [PubMed - indexed for MEDLINE]

Publication Types, MeSH Terms, Substances

Publication Types

Research Support, Non-U.S. Gov't

MeSH Terms

Substances

LinkOut - more resources

Full Text Sources

HighWire Press - PDF

Medical

Molecular Biology Databases

ETHYLENEDIAMINE TETRAACETIC ACID - HSDB

Supplemental Content

Save items

Related citations in PubMed

Increased intestinal permeability in ankylosing spondylitis--primary lesion or drug effect? [Gut. 1991]
Increased intestinal permeability in ankylosing spondylitis--primary lesion or drug effect?
Morris AJ, Howden CW, Robertson C, Duncan A, Torley H, Sturrock RD, Russell RI. Gut. 1991 Dec; 32(12):1470-2.
Intestinal permeability and inflammation in rheumatoid arthritis: effects of non-steroidal anti-inflammatory drugs. [Lancet. 1984]
Intestinal permeability and inflammation in rheumatoid arthritis: effects of non-steroidal anti-inflammatory drugs.
Bjarnason I, Williams P, So A, Zanelli GD, Levi AJ, Gumpel JM, Peters TJ, Ansell B. Lancet. 1984 Nov 24; 2(8413):1171-4.
[Non-steroidal anti-inflammatory agents increase intestinal permeability]. [Dtsch Med Wochenschr. 1987]
[Non-steroidal anti-inflammatory agents increase intestinal permeability].
Auer IO, Habscheid W, Hiller S, Gerhards W, Eilles C. Dtsch Med Wochenschr. 1987 Jun 26; 112(26):1032-7.
Review Experimental evidence of the benefit of misoprostol beyond the stomach in humans. [J Rheumatol Suppl. 1990]
Review Experimental evidence of the benefit of misoprostol beyond the stomach in humans.
Bjarnason I. J Rheumatol Suppl. 1990 Feb; 20:38-41.
Review Intestinal permeability to [51Cr]EDTA in infectious diarrhea. [Dig Dis Sci. 1993]
Review Intestinal permeability to [51Cr]EDTA in infectious diarrhea.
Zuckerman MJ, Watts MT, Bhatt BD, Ho H. Dig Dis Sci. 1993 Sep; 38(9):1651-7.

See reviews... See all...

Cited by 10 PubMed Central articles

Protective effect of metronidazole on uncoupling mitochondrial oxidative phosphorylation induced by NSAID: a new mechanism. [Gut. 2001]
Protective effect of metronidazole on uncoupling mitochondrial oxidative phosphorylation induced by NSAID: a new mechanism.
Leite AZ, Sipahi AM, Damião AO, Coelho AM, Garcez AT, Machado MC, Buchpiguel CA, Lopasso FP, Lordello ML, Agostinho CL, et al. Gut. 2001 Feb; 48(2):163-7.
High prevalence of NSAID enteropathy as shown by a simple faecal test. [Gut. 1999]
High prevalence of NSAID enteropathy as shown by a simple faecal test.
Tibble JA, Sigthorsson G, Foster R, Scott D, Fagerhol MK, Roseth A, Bjarnason I. Gut. 1999 Sep; 45(3):362-6.
Enhanced jejunal production of antibodies to Klebsiella and other Enterobacteria in patients with ankylosing spondylitis and rheumatoid arthritis. [Ann Rheum Dis. 1997]
Enhanced jejunal production of antibodies to Klebsiella and other Enterobacteria in patients with ankylosing spondylitis and rheumatoid arthritis.
Mäki-Ikola O, Hällgren R, Kanerud L, Feltelius N, Knutsson L, Granfors K. Ann Rheum Dis. 1997 Jul; 56(7):421-5.

See all...

Related information

Related Citations
Calculated set of PubMed citations closely related to the selected article(s) retrieved using a word weight algorithm. Related articles are displayed in ranked order from most to least relevant, with the “linked from” citation displayed first.
Compound (MeSH Keyword)
PubChem chemical compound records that are classified under the same Medical Subject Headings (MeSH) controlled vocabulary as the current articles.
Substance (MeSH Keyword)
PubChem chemical substance (submitted) records that are classified under the same Medical Subject Headings (MeSH) controlled vocabulary as the current articles.
Cited in PMC
Full-text articles in the PubMed Central Database that cite the current articles.

Recent activity

Clear Turn Off Turn On

Increased intestinal permeability in patients with rheumatoid arthritis: a side-...
Increased intestinal permeability in patients with rheumatoid arthritis: a side-effect of oral nonsteroidal anti-inflammatory drug therapy?
Br J Rheumatol. 1987 Apr ;26(2):103-7.

PubMed
Recurrence after surgical treatment of hidradenitis suppurativa.
Recurrence after surgical treatment of hidradenitis suppurativa.
Br Med J (Clin Res Ed). 1987 Feb 21 ;294(6570):487-9.

PubMed
alpha1-Antitrypsin deficiency in twins and parents-of-twins.
alpha1-Antitrypsin deficiency in twins and parents-of-twins.
Clin Genet. 1979 Jan ;15(1):29-36.

PubMed
Host, microbial, and pharmacological factors affecting the outcome of suppurativ...
Host, microbial, and pharmacological factors affecting the outcome of suppurative keratitis.
Br J Ophthalmol. 1987 Feb ;71(2):96-101.

PubMed
Lymphocytic thyroiditis, myasthenia gravis and Turner syndrome.
Lymphocytic thyroiditis, myasthenia gravis and Turner syndrome.
Birth Defects Orig Artic Ser. 1978 ;14(6A):137-47.

PubMed

Your browsing activity is empty.

Activity recording is turned off.

Turn recording back on

PubMed

Result Filters

Display Settings:

Send to: