Clin Genet. 1979 Jan;15(1):29-36.

alpha1-Antitrypsin deficiency in twins and parents-of-twins.

Abstract

Serum-trypsin-inhibitory-capacity (STIC) and alpha1-antitrypsin (AAT) genotypes were evaluated in 83 twins and 112 paired parents-of-twins. An increased prevalence (17.0--21.9%) of intermediate AAT deficiency (STIC less than 0.95 units/ml) was detected in both of these groups as compared to a prevalence of 4.1% in 1,841 healthy controls. PiS and PiZ molecular variants of AAT were also found more frequently in the twin and parent groups, but this was not statistically significant. Low levels of protease inhibition may enhance fertility and a tendency towards twinning, since proteolytic enzymes are involved in fertilization of ova by sperm and in gametogenesis. Increased fertility and twinning may be heterozygous advantages for AAT deficiency.

PMID:: 310370; [PubMed - indexed for MEDLINE]

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Research Support, U.S. Gov't, Non-P.H.S.

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alpha 1-Antitrypsin

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An excess of the Pi S allele in dizygotic twins and their mothers. [Hum Genet. 1982]
An excess of the Pi S allele in dizygotic twins and their mothers.
Clark P, Martin NG. Hum Genet. 1982; 61(2):171-4.
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Boomsma DI, Frants RR, Bank RA, Martin NG. Hum Genet. 1992 May; 89(3):329-32.
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Luisetti M, Seersholm N. Thorax. 2004 Feb; 59(2):164-9.
Review Twinning. [Lancet. 2003]
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Hall JG. Lancet. 2003 Aug 30; 362(9385):735-43.

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