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1: Int Urol Nephrol. 1986;18(4):363-8.Links

Induced precipitation of calcium-oxalate crystals and its prevention in laboratory animals.

Götz F, Gimes L, Hübler J, Temes G, Frang D.

Induced precipitation of Ca-oxalate crystals and the possibility of its prevention were studied in dogs. In the first phase of the experiments precipitation of Ca-oxalate crystals in canine renal tubules was induced by intraperitoneal administration of Na-glyoxylate. Preventive medication (lipoic acid, vitamin B1, Milurit), applied in the second phase, resulted in a significant depression of induced precipitation. The successful experiments serve as a basis for clinical research aimed at a preventive medication of recurrent Ca-oxalate stone formation.

PMID: 3102396 [PubMed - indexed for MEDLINE]

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