Intrapleural Alteplase and Dornase in a Pregnant Woman With Complicated Parapneumonic Effusion

Diana E Amariei; Bich-Chieu Tran; Roufan Yao; Edward M Britt; Van K Holden; Ashutosh Sachdeva; Edward M Pickering

doi:10.1016/j.athoracsur.2019.03.023

Intrapleural Alteplase and Dornase in a Pregnant Woman With Complicated Parapneumonic Effusion

Ann Thorac Surg. 2019 Nov;108(5):e293-e294. doi: 10.1016/j.athoracsur.2019.03.023. Epub 2019 Apr 9.

Authors

Diana E Amariei¹, Bich-Chieu Tran², Roufan Yao³, Edward M Britt², Van K Holden², Ashutosh Sachdeva², Edward M Pickering²

Affiliations

¹ Division of Pulmonary & Critical Care Medicine, University of Maryland School of Medicine, Baltimore, Maryland. Electronic address: dianama@bu.edu.
² Division of Pulmonary & Critical Care Medicine, University of Maryland School of Medicine, Baltimore, Maryland.
³ Gynecology & Reproductive Services, Department of Obstetrics, University of Maryland School of Medicine, Baltimore, Maryland.

PMID: 30978314
DOI: 10.1016/j.athoracsur.2019.03.023

Abstract

The use of intrapleural alteplase and dornase in pregnant patients remains an uncertain practice because bleeding complications in these cases could be devastating. We present a case in which we successfully used a modified protocol safely.

Publication types

Case Reports

MeSH terms

Adult
Deoxyribonuclease I / administration & dosage*
Female
Fibrinolytic Agents / administration & dosage*
Humans
Instillation, Drug
Pleural Cavity
Pleural Effusion / drug therapy*
Pregnancy
Pregnancy Complications / drug therapy*
Recombinant Proteins / administration & dosage
Tissue Plasminogen Activator / administration & dosage*

Substances

Fibrinolytic Agents
Recombinant Proteins
Deoxyribonuclease I
dornase alfa
Tissue Plasminogen Activator