Hospital Incidence and In-Hospital Mortality of Surgically and Interventionally Treated Aortic Dissections: Secondary Data Analysis of the Nationwide German Diagnosis-Related Group Statistics From 2006 to 2014

J Am Heart Assoc. 2019 Apr 16;8(8):e011402. doi: 10.1161/JAHA.118.011402.

Abstract

Background Population-based data about the incidence and mortality of patients with aortic dissections ( ADs ) are sparse. Therefore, the hospital incidence and in-hospital mortality of patients undergoing open or endovascular surgery for type A ADs ( TAADs ) and type B ADs ( TBADs ) in Germany were analyzed on a nationwide basis between 2006 and 2014. Methods and Results A secondary data analysis of the nationwide diagnosis-related group statistics, compiled by the German Federal Statistical Office, was performed for patients who were surgically/interventionally treated for AD ( International Classification of Diseases, Tenth Revision, German Modification [ ICD -10- GM] codes I71.00-I71.07; n=20 533). By using specific procedure codes, a distinction between TAAD (n=14 911/72.6%) and TBAD (n=5622/27.4%) could be made. The standardized hospital incidence of surgically/interventionally treated AD was 2.7/100 000 per year, comprising 2.0/100 000 per year for TAAD and 0.7/100 000 per year for TBAD . The in-hospital mortality of TAAD was 19.5%; and of TBAD, 9.3%. Both the incidence and in-hospital mortality increased over the 9-year period. The share of endovascularly treated TBAD increased steadily during the same time interval. A multilevel multivariable analysis revealed that, for TAAD , age and comorbidity were significantly associated with a higher mortality risk. The latter was also true for TBAD . Sex was not significantly associated with mortality. A significant association between higher annual center volume and mortality was found for TAAD , but not for TBAD . Conclusions This is the first report on hospital incidence and mortality for surgically/interventionally treated AD on a nationwide basis. Overall, in Germany, hospital incidence and mortality of TAAD and TBAD increased over time. In addition, TAAD is performed more safely in high-volume centers.

Keywords: aortic dissection; hospital incidence; in‐hospital mortality; secondary data analysis; type A aortic dissection; type B aortic dissection.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Aged
  • Aortic Aneurysm / epidemiology
  • Aortic Aneurysm / surgery*
  • Aortic Dissection / epidemiology
  • Aortic Dissection / surgery*
  • Cerebrovascular Disorders / epidemiology
  • Comorbidity
  • Diagnosis-Related Groups
  • Drosophila Proteins
  • Endovascular Procedures / methods*
  • Erythrocyte Transfusion
  • Extracorporeal Membrane Oxygenation
  • Female
  • Germany / epidemiology
  • Heart Failure / epidemiology
  • Heart-Lung Machine
  • Hospital Mortality*
  • Hospitals, High-Volume / statistics & numerical data
  • Hospitals, Low-Volume / statistics & numerical data
  • Humans
  • Hypertension / epidemiology
  • Incidence
  • Length of Stay
  • Male
  • Marfan Syndrome / epidemiology
  • Middle Aged
  • Myocardial Ischemia / epidemiology
  • Nuclear Matrix-Associated Proteins
  • Platelet Transfusion
  • Renal Insufficiency, Chronic / epidemiology
  • Vascular Surgical Procedures / methods*

Substances

  • Chro protein, Drosophila
  • Drosophila Proteins
  • Nuclear Matrix-Associated Proteins