C R Acad Sci III. 1986;303(8):295-7.

[Induction of remissions of insulin-dependent diabetes by cyclosporin].

[Article in French]

Feutren G, Papoz L, Assan R, Vialettes B, Pehuet M, Vexiau P, Durostu H, Rodier M, Sirmai J, Lallemand A, et al.

Abstract

The effect of cyclosporine was evaluated in a double blind placebo controlled trial in 122 recent onset insulin-dependent diabetics. A significantly higher incidence of complete remissions was observed in patients treated with cyclosporine than in those receiving placebo (respectively 24 and 5.8%). The effect was still more clear-cut in patients having presented the highest cyclosporine blood level (37%). These results which have been obtained with modest toxicity demonstrate that cyclosporine induces remission of insulin-dependent diabetes and prompt to set up new controlled trials to evaluate the duration of the effect obtained and the potential risks of the treatment.

PMID:: 3094846; [PubMed - indexed for MEDLINE]

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Cyclosporin increases the rate and length of remissions in insulin-dependent diabetes of recent onset. Results of a multicentre double-blind trial. [Lancet. 1986]
Cyclosporin increases the rate and length of remissions in insulin-dependent diabetes of recent onset. Results of a multicentre double-blind trial.
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McDonald JW, Feagan BG, Jewell D, Brynskov J, Stange EF, Macdonald JK. Cochrane Database Syst Rev. 2005 Apr 18; (2):CD000297. Epub 2005 Apr 18.

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[Induction of remissions of insulin-dependent diabetes by cyclosporin].

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