J Urol. 1986 Aug;136(2):497-500.

Evaluation of misoprostol cytoprotection of the bladder with cyclophosphamide (Cytoxan) therapy.

Gray KJ, Engelmann UH, Johnson EH, Fishman IJ.

Abstract

Cyclophosphamide is a well established cytotoxic drug used in the treatment of lymphoproliferative disorders, certain solid tumors, and nonneoplastic disorders such as nephrotic syndrome, systemic lupus erythematosus and rheumatoid arthritis. Hemorrhagic cystitis can be a complication of this drug varying between two and 40 per cent. Misoprostol, which is a synthetic prostaglandin E1 analog, was found to significantly decrease the histological damage to the bladder from cyclophosphamide. Male rats receiving misoprostol in conjunction with cyclophosphamide were found to have a reduction in ulceration, inflammation and edema of the bladder walls as compared to those treated with cyclophosphamide alone.

PMID:: 3090278; [PubMed - indexed for MEDLINE]

LinkOut - more resources

Molecular Biology Databases

Supplemental Content

Save items

Related citations in PubMed

Urinary complications of cyclophosphamide therapy: etiology, prevention, and management. [South Med J. 1983]
Urinary complications of cyclophosphamide therapy: etiology, prevention, and management.
Klein FA, Smith MJ. South Med J. 1983 Nov; 76(11):1413-6.
Prevention of cyclophosphamide cystitis with 2-mercaptoethane sodium sulfonate: a histologic study. [J Urol. 1984]
Prevention of cyclophosphamide cystitis with 2-mercaptoethane sodium sulfonate: a histologic study.
Freedman A, Ehrlich RM, Ljung BM. J Urol. 1984 Sep; 132(3):580-2.
Evaluation of effects of chitosan in preventing hemorrhagic cystitis in rats induced by cyclophosphamide. [Hinyokika Kiyo. 1995]
Evaluation of effects of chitosan in preventing hemorrhagic cystitis in rats induced by cyclophosphamide.
Okamura T, Masui T, St John MK, Cohen SM, Taylor RJ. Hinyokika Kiyo. 1995 Apr; 41(4):289-96.
Review Prevention and treatment of hemorrhagic cystitis. [Pharmacotherapy. 1997]
Review Prevention and treatment of hemorrhagic cystitis.
West NJ. Pharmacotherapy. 1997 Jul-Aug; 17(4):696-706.
Review Drug-induced bladder and urinary disorders. Incidence, prevention and management. [Drug Saf. 1998]
Review Drug-induced bladder and urinary disorders. Incidence, prevention and management.
Drake MJ, Nixon PM, Crew JP. Drug Saf. 1998 Jul; 19(1):45-55.

See reviews... See all...

Cited by 2 PubMed Central articles

Pharmacological and molecular evidence for kinin B1 receptor expression in urinary bladder of cyclophosphamide-treated rats. [Br J Pharmacol. 1999]
Pharmacological and molecular evidence for kinin B1 receptor expression in urinary bladder of cyclophosphamide-treated rats.
Belichard P, Luccarini JM, Defrêne E, Faye P, Franck RM, Duclos H, Paquet JL, Pruneau D. Br J Pharmacol. 1999 Sep; 128(1):213-9.
Involvement of nitric oxide in the pathogenesis of cyclophosphamide-induced hemorrhagic cystitis. [Am J Pathol. 1997]
Involvement of nitric oxide in the pathogenesis of cyclophosphamide-induced hemorrhagic cystitis.
Souza-Fiho MV, Lima MV, Pompeu MM, Ballejo G, Cunha FQ, Ribeiro Rde A. Am J Pathol. 1997 Jan; 150(1):247-56.

Related information

Related Citations
Calculated set of PubMed citations closely related to the selected article(s) retrieved using a word weight algorithm. Related articles are displayed in ranked order from most to least relevant, with the “linked from” citation displayed first.
Compound (MeSH Keyword)
PubChem chemical compound records that are classified under the same Medical Subject Headings (MeSH) controlled vocabulary as the current articles.
Substance
PubChem chemical substance records that cite the current articles. These references are taken from those provided on submitted PubChem chemical substance records.
Substance (MeSH Keyword)
PubChem chemical substance (submitted) records that are classified under the same Medical Subject Headings (MeSH) controlled vocabulary as the current articles.
Cited in PMC
Full-text articles in the PubMed Central Database that cite the current articles.

Recent activity

Clear Turn Off Turn On

Evaluation of misoprostol cytoprotection of the bladder with cyclophosphamide (C...
Evaluation of misoprostol cytoprotection of the bladder with cyclophosphamide (Cytoxan) therapy.
J Urol. 1986 Aug ;136(2):497-500.

PubMed
Comparison of living and nonliving vaccines for Brucella abortus in BALB/c mice.
Comparison of living and nonliving vaccines for Brucella abortus in BALB/c mice.
Infect Immun. 1986 Aug ;53(2):245-51.

PubMed
Overproduction of adenine deoxynucleosides and deoxynucletides in adenosine deam...
Overproduction of adenine deoxynucleosides and deoxynucletides in adenosine deaminase deficiency with severe combined immunodeficiency disease.
J Clin Invest. 1978 Oct ;62(4):884-7.

PubMed
Effect of maternal dietary exclusion on breast fed infants with eczema: two cont...
Effect of maternal dietary exclusion on breast fed infants with eczema: two controlled studies.
Br Med J (Clin Res Ed). 1986 Jul 26 ;293(6541):231-3.

PubMed
Current status of hormonal therapy of fibrocystic breast disease.
Current status of hormonal therapy of fibrocystic breast disease.
Ann N Y Acad Sci. 1986 ;464:350-63.

PubMed

Your browsing activity is empty.

Activity recording is turned off.

Turn recording back on

PubMed

Result Filters

Display Settings:

Send to:

Evaluation of misoprostol cytoprotection of the bladder with cyclophosphamide (Cytoxan) therapy.

Abstract

Publication Types, MeSH Terms, Substances

Publication Types

MeSH Terms

Substances

LinkOut - more resources

Molecular Biology Databases

Supplemental Content

Save items

Related citations in PubMed

Cited by 2 PubMed Central articles

Related information

Recent activity

Simple NCBI Directory

Getting Started

Resources

Popular

Featured

NCBI Information