Protective potency of recombinant meningococcal IgA1 protease and its structural derivatives upon animal invasion with meningococcal and pneumococcal infections

Olga Kotelnikova; Alexander Alliluev; Alexei Zinchenko; Larisa Zhigis; Yuri Prokopenko; Elena Nokel; Olga Razgulyaeva; Vera Zueva; Marina Tokarskaya; Natalia Yastrebova; Elena Gordeeva; Tatyana Melikhova; Elena Kaliberda; Lev Rumsh

doi:10.1016/j.micinf.2019.02.003

Protective potency of recombinant meningococcal IgA1 protease and its structural derivatives upon animal invasion with meningococcal and pneumococcal infections

Microbes Infect. 2019 Aug-Sep;21(7):336-340. doi: 10.1016/j.micinf.2019.02.003. Epub 2019 Feb 22.

Affiliations

¹ Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, ul. Miklukho-Maklaya 16/10, Moscow, 117997, Russia.
² Central Research Institute of Epidemiology of the Federal Service on Customers' Rights Protection and Human Well-Being Surveillance, ul. Novogireevskaya 3a, Moscow, 111123, Russia.
³ Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, ul. Miklukho-Maklaya 16/10, Moscow, 117997, Russia. Electronic address: zhigis@ibch.ru.
⁴ Mechnikov Research Institute for Vaccines and Sera, Malyi Kazennyi per. 5a, Moscow, 105064, Russia.

PMID: 30797878
DOI: 10.1016/j.micinf.2019.02.003

Abstract

Immunization of mice with recombinant IgA1 protease of Neisseria meningitidis or several structural derivatives thereof protects the animals infected with a variety of deadly pathogens, including N. meningitidis serogroups A, B, and C and 3 serotypes of Streptococcus pneumonia. In sera of rabbits immunized with inactivated pneumococcal cultures, antibodies binding IgA1-protease from N. meningitidis serogroup B were detected. Thus, the cross-reactive protection against meningococcal and pneumococcal infections has been demonstrated in vivo. Presumably it indicates the presence of common epitopes in the N. meningitidis IgA1 protease and S. pneumoniae surface proteins.

Keywords: Epitopes; IgA1 protease; Meningococcal vaccines; Neisseria meningitidis; Streptococcus pneumoniae.

MeSH terms

Animals
Antibodies, Bacterial / blood
Antibodies, Bacterial / immunology
Cross Protection
Female
Immune Sera / administration & dosage
Immune Sera / immunology
Meningococcal Infections / immunology
Meningococcal Infections / prevention & control*
Meningococcal Vaccines / administration & dosage
Meningococcal Vaccines / immunology*
Mice, Inbred BALB C
Neisseria meningitidis / enzymology
Neisseria meningitidis / immunology*
Pneumococcal Infections / immunology
Pneumococcal Infections / prevention & control*
Rabbits
Recombinant Proteins / immunology*
Serine Endopeptidases / chemistry
Serine Endopeptidases / immunology*
Streptococcus pneumoniae / immunology*
Vaccines, Synthetic / administration & dosage
Vaccines, Synthetic / immunology

Substances

Antibodies, Bacterial
Immune Sera
Meningococcal Vaccines
Recombinant Proteins
Vaccines, Synthetic
Serine Endopeptidases
IgA-specific serine endopeptidase