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Am J Nephrol. 1988;8(3):235-9.

Membranoproliferative glomerulonephritis in a patient with primary Sjögren's syndrome. Report of a case with review of the literature.

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  • 1King Faisal Specialist Hospital, Riyadh, Saudi Arabia.


Glomerulonephritis complicating primary Sjögren's syndrome is extremely rare, with only 3 cases of membranoproliferative glomerulonephritis reported in the literature. We report on a 55-year-old woman with a long-standing history of dryness of the mouth and eyes who was found to have nephrotic syndrome. Extensive investigations indicated primary Sjögren's syndrome. Kidney biopsy revealed a membranoproliferative glomerulonephritis. Treatment with prednisone and cyclophosphamide resulted in complete remission of nephrotic syndrome. The pathogenesis of glomerulonephritis appears to be due to deposition of circulating immune complexes.

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