Atoh1/MATH1 Adds Up to Ciliogenesis for Transducing SHH Signaling in the Cerebellum

Robert C Castellino; Anna Marie Kenney

doi:10.1016/j.devcel.2019.01.012

Atoh1/MATH1 Adds Up to Ciliogenesis for Transducing SHH Signaling in the Cerebellum

Dev Cell. 2019 Jan 28;48(2):129-130. doi: 10.1016/j.devcel.2019.01.012.

Authors

Robert C Castellino¹, Anna Marie Kenney²

Affiliations

¹ Department of Pediatrics, Emory University, Atlanta, GA 303022, USA.
² Department of Pediatrics, Emory University, Atlanta, GA 303022, USA. Electronic address: anna.kenney@emory.edu.

PMID: 30695693
DOI: 10.1016/j.devcel.2019.01.012

Abstract

In the developing cerebellum, Sonic hedgehog (SHH) signaling is required for expansion of cerebellar granule neural progenitors, proposed to be cells-of-origin for the SHH-driven pediatric brain tumor medulloblastoma. In this issue of Developmental Cell, Chang et al. (2019) show that the transcription factor Atoh1/MATH1 regulates primary cilium formation, enabling SHH signaling.

Publication types

Comment

MeSH terms

Basic Helix-Loop-Helix Transcription Factors
Cell Proliferation
Cerebellar Neoplasms*
Cerebellum
Child
Cilia
Hedgehog Proteins
Humans
Medulloblastoma*
Neurons

Substances

ATOH1 protein, human
Basic Helix-Loop-Helix Transcription Factors
Hedgehog Proteins
SHH protein, human