Toxicity of a molluscicide candidate PPU07 against Oncomelania hupensis (Gredler, 1881) and local fish in field evaluation

Zhuo Chen; Weisi Wang; Junmin Yao; Shizhu Li; Xia Zhang; Hehua Hu; Xiong Liu; Binrong Luo; Yuhua Liu; Huiyong Xu; Liping Duan

doi:10.1016/j.chemosphere.2019.01.102

Toxicity of a molluscicide candidate PPU07 against Oncomelania hupensis (Gredler, 1881) and local fish in field evaluation

Chemosphere. 2019 May:222:56-61. doi: 10.1016/j.chemosphere.2019.01.102. Epub 2019 Jan 21.

Authors

Zhuo Chen¹, Weisi Wang², Junmin Yao², Shizhu Li³, Xia Zhang⁴, Hehua Hu⁴, Xiong Liu⁴, Binrong Luo⁵, Yuhua Liu⁵, Huiyong Xu⁶, Liping Duan⁷

Affiliations

¹ Shanghai Key Laboratory of New Drug Design, School of Pharmacy, East China University of Science and Technology, Shanghai 200237, China.
² National Institute of Parasitic Diseases, Chinese Center for Disease Control and Prevention, WHO Collaborating Centre for Malaria, Schistosomiasis, and Filariasis, Key Laboratory of Parasitology and Vector Biology of the Chinese Ministry of Health, Shanghai 200025, China.
³ National Institute of Parasitic Diseases, Chinese Center for Disease Control and Prevention, WHO Collaborating Centre for Malaria, Schistosomiasis, and Filariasis, Key Laboratory of Parasitology and Vector Biology of the Chinese Ministry of Health, Shanghai 200025, China. Electronic address: stoneli1130@126.com.
⁴ Jianglin Institute for Schistosomiasis Control, Hubei 434100, China.
⁵ Dali Institute for Schistosomiasis Control, Yunnan 671000, China.
⁶ Jiangsu Academy of Agricultural Sciences, Jiangsu 210014, China.
⁷ National Institute of Parasitic Diseases, Chinese Center for Disease Control and Prevention, WHO Collaborating Centre for Malaria, Schistosomiasis, and Filariasis, Key Laboratory of Parasitology and Vector Biology of the Chinese Ministry of Health, Shanghai 200025, China; Jiangsu Academy of Agricultural Sciences, Jiangsu 210014, China; The Institute of Microbiology of the Chinese Academy of Sciences, Beijing 100101, China. Electronic address: duanlp@nipd.chinacdc.cn.

PMID: 30690401
DOI: 10.1016/j.chemosphere.2019.01.102

Abstract

Schistosomiasis japonica caused by Schistosoma japonicum infection is recognized as a considerable economic and public health concern in Asia. Oncomelania hupensis is the sole intermediate host of S. japonicum. The only molluscicide recommended by World Health Organization (WHO) since 1960s is relative toxic to other aquatic species. In this article, we evaluated the novel molluscicide PPU07 in field trials on their efficiency against O. hupensis and toxicity for local fish. 25% PPU07 sulfate WP exhibited similar molluscicidal effect at 2.0 g/m² and 2.0 g/m³ in the spraying and immersion trials with the WHO recommended molluscicide niclosamide (1 g/m² and 1 g/m³). The mortality rates reached 95% and 96%, respectively. Moreover, little toxicity was observed for local fish and other aquatic organisms at the effective molluscicidal concentrations. In all, 25% PPU07 sulfate WP is a promising molluscicide for snail control, particularly in semi-commercial or commercial aquaculture ponds.

Keywords: Fish toxicity; Molluscicide; Oncomelania hupensis; PPU07; Schistosoma japonicum.

MeSH terms

Animals
Asia
Fishes / physiology*
Molluscacides / toxicity*
Niclosamide / toxicity
Schistosoma japonicum / drug effects
Snails / drug effects*
Survival Analysis

Substances

Molluscacides
Niclosamide