Scotopic multifocal visual evoked potentials

Objective: To investigate the scope of scotopic multifocal visual evoked potentials (mfVEP_S) for the assessment of scotopic visual fields.

Methods: Pattern-reversal mfVEP for photopic (mfVEP_P) and scotopic conditions (mfVEP_S; 0.003 cd/m²) were recorded from 36 visual field locations of a circular checkerboard pattern (25° radius) in 9 participants with normal vision. MfVEP_P were recorded with a conventional central fixation cross, mfVEP_S were recorded (i) with (mfVEP_S+) and (ii) without (mfVEP_S-) an additional fixation aid. Latency shifts were determined using cross-correlations, mfVEP magnitudes were analysed in an eccentricity dependent manner using signal-to-noise ratios (SNRs).

Results: In comparison to mfVEP_P, mfVEP_S- and mfVEP_S+ were delayed by 101 ms and 97 ms, respectively, and had smaller signal-to-noise-ratios. Both mfVEP_S were reduced down to noise level in the center and also severely reduced for the most peripheral stimulus eccentricity used. The visual-field-coverage for the paracentral eccentricities of mfVEP_S+ and mfVEP_S- was 76% and 65% [4°-9°], respectively, and 79% and 66% [9°-16°].

Conclusions: MfVEP_S were delayed compared to mfVEP_P and demonstrated the expected central response drop-out typical for scotopic vision.

Significance: MfVEP_S may hold promise of an objective, spatially resolved visual field test which motivates testing it in patients with diseases affecting scotopic vision.