[Primary cutaneous localization revealing leukemia/T-cell lymphoma associated with chronic HTLV-1 infection in a adult. A case presentation]

Ann Pathol. 2019 Feb;39(1):40-46. doi: 10.1016/j.annpat.2018.10.001. Epub 2018 Dec 19.
[Article in French]

Abstract

Adult T-cell leukemia/lymphoma (ATLL) is a rare medical condition and a diagnosis that ought to be considered for patients living in an area endemic for the HTLV-1 virus (human T-lymphotrophic virus) where a T-cell lymphoproliferative diagnosis has been made. The cutaneous clinical forms may be the first manifestation of the disease. We report here an observation in a 60-year-old Senegalese woman whose skin lesions were sampled to reveal the ATLL immunophenotypic profile CD4+, CD25+, FoxP3-, and CD7-. HTLV-1 seropositivity confirmed the histopathological diagnosis, and should be corroborated by demonstration of a molecular clonal rearrangement by PCR (Polymerase Chain Reaction). This is a problem because such techniques are not always available in Africa.

Keywords: Adult leukemia T-cell lymphoma; Biopsie cutanée; Clonalité; Clonally; Cutaneous biopsy; Immunohistochemistry; Immunohistochimie; Leucémie lymphome ATLL.

Publication types

  • Case Reports

MeSH terms

  • Chronic Disease
  • Female
  • HTLV-I Infections / complications*
  • Humans
  • Leukemia-Lymphoma, Adult T-Cell / virology*
  • Middle Aged
  • Skin Neoplasms / virology*