RETRACTED: Bimodal Distribution of Nuclear Factor-κB Activation and Expression of Subunits in Experimental Models of Intracerebral Hemorrhage In Vivo

Ze-Li Zhang; Yan Song; Feng Li; Qi-Bing Huang

doi:10.1016/j.jstrokecerebrovasdis.2018.11.028

RETRACTED: Bimodal Distribution of Nuclear Factor-κB Activation and Expression of Subunits in Experimental Models of Intracerebral Hemorrhage In Vivo

J Stroke Cerebrovasc Dis. 2019 Mar;28(3):821-829. doi: 10.1016/j.jstrokecerebrovasdis.2018.11.028. Epub 2018 Dec 14.

Authors

Ze-Li Zhang¹, Yan Song², Feng Li², Qi-Bing Huang³

Affiliations

¹ Department of Neurosurgical Intensive Care Unit, Qilu Hospital of Shandong University and Brain Science Research Institute of Shandong University, Jinan, Shandong Province, China.
² Department of Neurosurgery, Qilu Hospital of Shandong University and Brain Science Research Institute of Shandong University, Jinan, Shandong Province, China.
³ Department of Neurosurgical Intensive Care Unit, Qilu Hospital of Shandong University and Brain Science Research Institute of Shandong University, Jinan, Shandong Province, China. Electronic address: cnyuguangliu@163.com.

PMID: 30558860
DOI: 10.1016/j.jstrokecerebrovasdis.2018.11.028

Abstract

This article has been retracted: please see Elsevier Policy on Article Withdrawal (https://www.elsevier.com/about/our-business/policies/article-withdrawal). This article has been retracted at the request of the authors as it contains erroneous experimental results, pictures, discussions and conclusions related to IL-1β and TNF-α. The authors were unable to repeat the experimental results of IL-1β and TNF-α in the subsequent 2 repeated experiments. We apologise and inform the readers of the journal that the conclusions of the manuscript are invalid.

Keywords: Intracerebral hemorrhage; bimodal distribution; cell death; inflammatory response; nuclear factor-kappaB.

Publication types

Retracted Publication

MeSH terms

Animals
Apoptosis
Brain / metabolism*
Brain / pathology
Caspase 3 / metabolism
Cerebral Hemorrhage / metabolism*
Cerebral Hemorrhage / pathology
Disease Models, Animal
Inflammation Mediators / metabolism*
Interleukin-1beta / metabolism
Male
NF-kappa B / metabolism*
NF-kappa B p50 Subunit / metabolism
Proto-Oncogene Proteins c-bcl-2 / metabolism
Proto-Oncogene Proteins c-rel / metabolism
Rats, Wistar
Time Factors
Transcription Factor RelA / metabolism
Tumor Necrosis Factor-alpha / metabolism

Substances

Bcl2 protein, rat
IL1B protein, rat
Inflammation Mediators
Interleukin-1beta
NF-kappa B
NF-kappa B p50 Subunit
Proto-Oncogene Proteins c-bcl-2
Proto-Oncogene Proteins c-rel
Rela protein, rat
Transcription Factor RelA
Tumor Necrosis Factor-alpha
Casp3 protein, rat
Caspase 3