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1: J Clin Psychiatry. 1988 Nov;49(11):422-6.Links

Fluoxetine versus trazodone in the treatment of outpatients with major depression.

Debus JR, Rush AJ, Himmel C, Tyler D, Polatin P, Weissenburger J.

Department of Psychiatry, University of Texas Southwestern Medical Center, Dallas 75235.

Fluoxetine and trazodone were compared in a double-blind, randomized, parallel, 6-week trial in 43 outpatients with major depression after a 1-week single-blind placebo period. Thirty-five patients completed at least 3 weeks of active medication, while 25 patients completed all 6 weeks. Response rates, whether defined by end-of-treatment Hamilton Rating Scale for Depression (HAM-D) score less than 10 or by a 50% reduction in HAM-D scores, were equivalent for the two medications. For fluoxetine, HAM-D scores were significantly lower at Weeks 1 and 2 compared with those of trazodone. Trazodone improved sleep significantly more than fluoxetine. Fluoxetine was associated more frequently with weight loss (p = .002) and less frequently with dizziness (p = .04) than trazodone.

PMID: 3053668 [PubMed - indexed for MEDLINE]

Patient Drug Information

  • Fluoxetine (Prozac® , Prozac® Weekly, Sarafem® , ...)

    Fluoxetine (Prozac) is used to treat depression, obsessive-compulsive disorder (bothersome thoughts that won't go away and the need to perform certain actions over and over), some eating disorders, and panic attacks (sud...

  • Bupropion (Wellbutrin, Wellbutrin, Wellbutrin XL, ...)

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  • Trazodone

    Trazodone is used to treat depression. Trazodone is in a class of medications called serotonin modulators. It works by increasing the amount of serotonin, a natural substance in the brain that helps maintain mental balan...

  • Source: AHFS Consumer Medication Information