SEOM clinical guidelines for the diagnosis and treatment of gastroenteropancreatic and bronchial neuroendocrine neoplasms (NENs) (2018)

Clin Transl Oncol. 2019 Jan;21(1):55-63. doi: 10.1007/s12094-018-1980-7. Epub 2018 Dec 7.

Abstract

NENs are a heterogeneous family of tumors of challenging diagnosis and clinical management. Their incidence and prevalence continue to rise across all sites, stages and grades. Although improved diagnostic techniques have led to earlier detection and stage migration, the improved prognosis documented over time for advanced gastrointestinal and pancreatic neuroendocrine tumors also reflect improvements in therapy. The aim of this guideline is to update practical recommendations for the diagnosis and treatment of gastroenteropancreatic and lung NENs. Diagnostic procedures, histological classification and therapeutic options are briefly discussed, including surgery, liver-directed therapy, peptide receptor radionuclide therapy, and systemic hormonal, cytotoxic or targeted therapy, and treatment algorithms are provided.

Keywords: Diagnosis; Gastroenteropancreatic; Guidelines; Lung; Neuroendocrine neoplasms; Neuroendocrine tumors; Therapy.

MeSH terms

  • Bronchial Neoplasms / diagnosis
  • Bronchial Neoplasms / therapy*
  • Clinical Trials as Topic
  • Combined Modality Therapy
  • Disease Management
  • Gastrointestinal Neoplasms / diagnosis
  • Gastrointestinal Neoplasms / therapy*
  • Humans
  • Neuroendocrine Tumors / diagnosis
  • Neuroendocrine Tumors / therapy*
  • Pancreatic Neoplasms / diagnosis
  • Pancreatic Neoplasms / therapy*
  • Practice Guidelines as Topic / standards*
  • Prognosis
  • Societies, Medical