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Rheumatic disorders in primary biliary cirrhosis.
Eighty-three patients with primary biliary cirrhosis were investigated to determine the prevalence of rheumatic disorders. 14 had scleroderma, which tended to be mild but in several patients produced severe systemic manifestations. The CRST syndrome (calcinosis, Raynaud's phenomenon, sclerodactyly, telangiectasia) was only identified twice. There was an increased incidence of HLA A1+B8 in those patients with scleroderma. As well as those with scleroderma, 4 patients had a destructive arthropathy resembling avascular necrosis. 4 patients had an inflammatory arthritis, without specific features, but the frequency was no greater than might be expected in the general population.
PMID: 305233 [PubMed - indexed for MEDLINE]
PMCID: PMC1000187
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Cited by 17 PubMed Central articles
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Clinical features and prognosis of primary biliary cirrhosis associated with systemic sclerosis.
Rigamonti C, Shand LM, Feudjo M, Bunn CC, Black CM, Denton CP, Burroughs AK.
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[Gut. 2006]
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Rheumatic disorders and primary biliary cirrhosis: an appraisal of 170 Italian patients.
Marasini B, Gagetta M, Rossi V, Ferrari P.
Ann Rheum Dis. 2001 Nov; 60(11):1046-9.
[Ann Rheum Dis. 2001]
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Increased C1q binding and arthritis in primary biliary cirrhosis.
Crowe JP, Molloy MG, Wells I, Thompson BR, Holborow EJ, Hamilton E, Williams R.
Gut. 1980 May; 21(5):418-22.
[Gut. 1980]
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